Build Better Biomedical Hydrogels From Molecular Building Blocks to High-Order Structures

Hydrogels have become essential to modern biomedicine, enabling advances in drug delivery, tissue engineering and wearable healthcare. Researchers have proposed an architecture-based framework for designing high-performance hydrogels beyond conventional, randomly crosslinked networks. Their review defines hydrogels with high-order structures, outlines four construction routes, including phase separation, molecular self-assembly, nanocomposite integration and polymer crystallization, and links multiscale organization to mechanical robustness, transport control and integrated biomedical functions.